Biochemical attributes of mitotic and meiotic presynaptic complexes
نویسندگان
چکیده
منابع مشابه
Novel attributes of Hed1 affect dynamics and activity of the Rad51 presynaptic filament during meiotic recombination.
During meiosis, recombination events that occur between homologous chromosomes help prepare the chromosome pairs for proper disjunction in meiosis I. The concurrent action of the Rad51 and Dmc1 recombinases is necessary for an interhomolog bias. Notably, the activity of Rad51 is tightly controlled, so as to minimize the use of the sister chromatid as recombination partner. We demonstrated recen...
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چکیده ندارد.
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Polymers tied together by constraints exhibit an internal pressure; this idea is used to analyze physical properties of the bottle-brush-like chromosomes of meiotic prophase that consist of polymer-like flexible chromatin loops, attached to a central axis. Using a minimal number of experimental parameters, semiquantitative predictions are made for the bending rigidity, radius, and axial tension...
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Accurate control of spindle length is a conserved feature of eukaryotic cell division. Lengthening of mitotic spindles contributes to chromosome segregation and cytokinesis during mitosis in animals and fungi. In contrast, spindle shortening may contribute to conservation of egg cytoplasm during female meiosis. Katanin is a microtubule-severing enzyme that is concentrated at mitotic and meiotic...
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Meiotic crossovers facilitate the segregation of homologous chromosomes and increase genetic diversity. The formation of meiotic crossovers was previously posited to occur via two pathways, with the relative use of each pathway varying between organisms; however, this paradigm could not explain all crossovers, and many of the key proteins involved were unidentified. Recent studies that identify...
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ژورنال
عنوان ژورنال: DNA Repair
سال: 2018
ISSN: 1568-7864
DOI: 10.1016/j.dnarep.2018.08.018